Phytochemical Screening And Antiepileptic Activity Of Hydroalcoholic Extract Of Clerodendrum Serratum

Abstract

The present study aimed to investigate the phytochemical profile and antiepileptic potential of the hydroalcoholic extract of Clerodendrum serratum. The extract was prepared and subjected to preliminary phytochemical screening, revealing the presence of flavonoids, phenols, proteins, carbohydrates, and diterpenes. Quantitative analysis showed total flavonoid and phenol contents of 0.860 mg/100 mg and 0.572 mg/100 mg of dried extract, respectively. The antiepileptic activity was evaluated using pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizure models in albino rats. The extract exhibited a dose-dependent protective effect against PTZ-induced seizures, delaying seizure onset and providing 66.67% and 74.36% protection at 100 mg/kg and 200 mg/kg doses, respectively. In the MES model, it significantly delayed seizure onset, indicating anticonvulsant potential. The observed activity may be attributed to the presence of flavonoids and phenolic compounds, which possess antioxidant and neuroprotective properties. These findings support the traditional use of Clerodendrum serratum in neurological disorders and suggest its potential as a source of novel antiepileptic agents.