Synthesis Of Some Novel Pyrazole-Derivatives And Evaluation Of Their Biological Activity As Putative Anti-Inflammatory And Antioxidant Agent

Abstract

Pyrazole derivatives have emerged as promising anti-inflammatory agents targeting p38α MAP kinase, a key enzyme in inflammatory signaling. In this study, several pyrazole-based compounds were synthesized and evaluated for ulcerogenic potential, lipid peroxidation inhibition, LPS-induced TNF-α suppression, and p38α MAP kinase inhibition, showing IC₅₀ values in the nanomolar range. Structural characterization was performed using IR, NMR, and mass spectrometry. Structure–activity relationship analysis revealed crucial features contributing to enzyme inhibition, offering insights for rational drug design. The most active compounds displayed strong selectivity and lower cytotoxicity compared to standard anti-inflammatory drugs. These findings highlight pyrazole scaffolds as potential leads for novel anti-inflammatory agents with antioxidant properties. Further optimization and in vivo evaluation are needed to confirm therapeutic applicability.