Effect Of Wound Care With Garcinia Mangostana Linn Nanoparticle Spray On Diabetic Foot Wound Healing Animal Studies On Tnf-Α, Fibroblasts, And Wound Area
DOI:
https://doi.org/10.64252/sm67sa43Keywords:
Diabetic foot wound, Garcinia mangostana Linn, nanoparticle spray, wound care, wound healingAbstract
Diabetic foot wounds pose a major challenge in clinical management, requiring innovative approaches for effective wound care. This study explores the potential of natural materials for wound care using Garcinia mangostana Linn nanoparticle spray in facilitating the wound healing process in diabetic feet. The main objective of this study was to evaluate the effect of Garcinia mangostana Linn nanoparticle spray on diabetic foot wound healing. The investigation focused on TNF-α levels, fibroblast activity, and wound area as the main parameters. This study used an experimental design involving a diabetic experimental animal model. Wound care interventions were performed using Garcinia mangostana Linn nanoparticle spray, and the effects were assessed through measurements of TNF-α levels, fibroblast response, and wound size. Statistical analysis was performed to determine the significance of the observed effects. The findings of this study showed that treatment with Garcinia Mangostana Linn extract significantly affected wound size in diabetic patients, with a significance level of p=0.013. In addition, there was a significant difference in TNF-α levels at p=0.001 indicating the potential of Garcinia Mangostana Linn extract in the mechanism of inflammation in diabetic wounds. The significant result at p=0.000 for fibroblast response confirmed that Garcinia Mangostana Linn extract strongly influenced fibroblast cell response, which may affect collagen production and support new tissue formation in wound healing. Overall, the application of Garcinia mangostana Linn nanoparticle spray showed influence in improving wound healing in diabetic foot. The observed effects on wound size, TNF-α levels, and fibroblast response emphasize the potential therapeutic benefits of Garcinia Mangostana Linn extract in the context of diabetic wound care.