Wound Healing Activity Of Himavan Agad - A Review Article

Abstract

Background: Wound healing is a multifactorial biological process influenced by infection, inflammation, oxidative stress, and tissue regeneration. Classical Ayurvedic texts describe numerous formulations under vrana chikitsa for cleansing (shodhana) and healing (ropana) of wounds. Himavan Agad, a polyherbal formulation mentioned in Aṣhṭanga Hṛidaya and Aṣhtanga Sangraha, is primarily indicated in toxic and inflammatory dermatoses but exhibits properties relevant for wound care.

Objective: To critically review classical references, phytochemical composition, and pharmacological evidence of Himavan Agad in relation to wound healing.

Methods: Literature was reviewed using PubMed, ScienceDirect, AYUSH Research Portal, and Google Scholar. Classical Ayurvedic texts, postgraduate theses, and pharmacognostical monographs were also screened. Data on phytochemistry, pharmacological actions, and wound-healing potential of individual ingredients were synthesized.

Results: Himavan Agad contains 17 ingredients including Ficus species (Nyagrodha, Udumbara, Ashvattha, Plaksha), Triphala (Haritaki, Bibhitaka, Amalaki), Yaṣhṭimadhu, Nagapuṣhpa, Chandana, Padmaka, Utpala, Elavaluka, Jivaka, Ṛuṣabhaka, and Madhu. Preclinical studies report anti-inflammatory, antioxidant, antimicrobial, and angiogenic activities. Animal models demonstrate accelerated wound contraction, enhanced granulation tissue, and improved epithelialization. Compared to modern topical agents, Himavan Agad shows broader multi-target effects with minimal adverse risks. Conclusion: Himavan Agad embodies Ayurvedic principles of shodhana and ropana, acting through antimicrobial, anti-inflammatory, and tissue-regenerative mechanisms. Clinical validation, standardization, and development of novel dosage forms are essential to integrate this formulation into modern wound care.