Stoneease: A Synergistic Herbal Syrup With Citrus Medica Linn., Rubia Cordifolia, And Bryophyllum Pinnatum For Natural Kidney Stone Relief
DOI:
https://doi.org/10.64252/mdtjaw47Keywords:
Kidney stone, Medicinal plant, Nephrolithiasis, Bijora fruit, HerbsAbstract
Nephrolithiasis, commonly known as kidney stones, is a prevalent urinary tract disorder affecting nearly 12% of the global population, with over 600,000 new cases reported annually in India. These stones are typically composed of calcium oxalate and calcium phosphate, forming when urinary mineral concentration exceeds solubility limits. Conventional treatment approaches aim to adjust urinary composition through dietary or pharmacological modifications. The present study focuses on the development and assessment of a novel polyherbal syrup formulated with Citrus medica Linn., Rubia cordifolia, and Bryophyllum pinnatum, all recognized for their anti-urolithiatic, antioxidant, and anti-inflammatory effects. In particular, Citrus medica contains high levels of citric acid, which may help prevent crystal formation by binding calcium and increasing urinary pH. The syrup was formulated as a sugar-based aqueous oral preparation, ensuring patient compliance and enhanced palatability. Key formulation parameters such as pH, viscosity, specific gravity, and density were systematically evaluated. The anti-urolithiatic potential was investigated through in vitro dissolution studies mimicking kidney stone breakdown. Furthermore, the stability of the herbal formulation was analyzed following ICH guidelines to ensure its shelf life and efficacy. This study highlights the therapeutic promise of combining traditional herbal knowledge with contemporary formulation science in addressing nephrolithiasis. The results indicate that this herbal syrup could serve as a viable, natural alternative to conventional treatments, contributing to improved renal health and patient well-being.