Design, Synthesis, And Pharmacological Evaluation Of 7-Nitro-2-(4-Nitrophenyl)-3-Substituted Phenylquinazoline-4(3H)-One Derivatives As Potential Anti-Inflammatory Agents
DOI:
https://doi.org/10.64252/1hdwgd15Keywords:
Anti-inflammatory, quinazolone derivatives, FTIR characterization, in-vivo assays, drug development.Abstract
The current work was devoted to the production of 7-nitro-2- (4- nitrophenyl)-3-substituted phenylquinazol- 4(3H)- one derivatives and their anti-inflammatory properties assessment. FTIR, mass spectrometry and ^1H NMR were used to characterize the synthesized compounds thoroughly, confirming the structural integrity of the compounds. To determine the anti-inflammatory effects, in-vitro and in-vivo models were conducted namely; egg albumin denaturation assay, carrageenan-induced paw edema and cotton pellet granuloma tests. It was found that all compounds synthesized possessed considerable anti-inflammatory activity, with compounds S1 and S3 proving to show the most promising activities. S1 was among these, demonstrating a potent anti-inflammatory effect, in addition to a high potential in breast cancer. Additionally, there is an early indication that these derivatives can be structurally modified to increase their therapeutic efficacy especially in brain cancer, and therefore they could be used as leads in future drug development.
