Formulation And InVitro Evaluation Of Oral Fast Dissolving Tablet Using Antimigraine Drug

Abstract

The main objective of this research work was to formulate and evaluate fast dissolving tablet of Zolmitriptan for the treatment of migraine. In this study, fast dissolving tablet were prepared by Direct Compression Method by using croscarmellose sodium, Crospovidone and sodium starch glycolate as Fast Disintegrating Polymers or superdisintegrant. Mannitol is used as a binder. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content. All the prepared formulations were subjected to various assessment parameters, and the findings obtain within the prescribed limit. The calibration curve of pure drug using various solvents like distilled water, phosphate buffer pH 6.8, 0.1 N HCL was plotted. The disintegration time of three formulations (F1-F3) was good passes of the reference of book. But the above remaining formulation (F4-F9) was in the range. % Drug Release of Fast dissolving tablet (F1-F9) was found to be range (92.33±0.015) to (101.17 ±0.5661). It was observed that Cumulative % Drug release of dissolving tablets depend on concentration of polymer (Croscarmellose, crospovidone, Sodium starch glycolate). The results obtained in the research work clearly showed a promising potential of fast dissolving tablets containing a specific ratio of croscarmellose sodium and sodium starch glycolate as superdisintegrants for the effective treatment of hypertension.