Degradation Studies for Combination of Three Antidiabetic Medicines by UPLC

Abstract

Forced degradation studies include the degradation of new drug substance and drug product at conditions more severe than accelerated conditions. Dapagliflozin + Metformin + Vildagliptin is a combination of three antidiabetic medicines. These studies illustrate the chemical stability of the molecule which further facilitates the development of stable formulation with suitable storage conditions. ICH guidelines demonstrate certain degradation conditions like light, oxidation, dry heat, acidic, basic, hydrolysis etc.