The Study of DES via Sonochemistry method in Synthesis of 2,3-dihydroquinazolin-4(1H)- ones derivatives

Abstract

Deep eutectic solvents (DESs) have emerged as viable alternatives to ionic liquids (ILs) and conventional organic solvents for organic syntheses. DESs exhibit distinctive properties compared to traditional solvents and ILs, including a low vapor pressure, the ability to dissolve reagents that are insoluble in common organic solvents, and the capacity to alter the overall pH of the medium by substituting one of the components of the mixture. DESs can be synthesized by combining molecules derived from natural sources such as PEG-400 to ensure biodegradability. The initial study and synthesis of DESs was conducted by Ijardar [1,1.1]. The catalytic activity of the DES (PEG-400:TBAB) was evaluated in a reaction involving a series of aldehydes and 2-amino-benzamide under son                                                                                                                                                                                                                                                                                                                                                                                                                                          ochemical conditions. DES (TBAB: PEG-400)(1:3) was synthesized using a straightforward method with readily available starting materials, and its structure was confirmed by FTIR (Fourier Transform Infrared Spectroscopy (FTIR). This protocol was characterized by a green and efficient catalyst as well as solvent, ease of workup, simple separation without chromatography, and the reusability of the DES up to four cycles. These features suggest that it can find extensive applications in future research, green chemistry, and innovation.