Synthesis, Characterization And Thermal Decomposition Of N- (3-Butyl-2, 6-Diphenylpiperidin-4-Ylidene)Isonicotinohydrazide-Non-Isothermal Condition

Abstract

Background: The compound N-(3-butyl-2,6-diphenylpiperidin-4-ylidene)isonicotinohydrazide (BDPINH) was synthesized through a condensation reaction involving piperidin-4-one, isoniazid and sodium acetate trihydrate in an ethanol medium. The reaction mixture was refluxed at 80°C for 12 hours.

Objective: The resulting product was characterized using FT-IR and NMR spectroscopies. To investigate its thermal behavior, thermal decomposition studies were performed using a system combined with thermogravimetric analysis (TG), differential thermal analysis (DTA) and differential thermogravimetric analysis (DTG) under a dynamic nitrogen atmosphere across variable temperatures.

Methods: Kinetic and thermodynamic parameters were derived using iso-conversional model-free methods such as the Friedman, Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) . Additionally, the Coats–Redfern method was used for model-fitting analysis.

Results: The TG curves indicated a single-step decomposition pathway. Activation energy (Ea) values and correlation coefficients (r) were calculated and graphically represented using the isoconversional techniques. Theoretical reaction models were compared with the experimental data, revealing that the compound decomposes follow a two-dimensional diffusion mechanism (D2 model).

Conclusion: Both kinetic and thermodynamic parameters were compiled in table form and visualized through the graphical plots.