Herbal Nanotechnology: A Novel Approach In Designing Polyherbal Formulations For Diabetes Therapy

Abstract

The impeding problem of diabetes mellitus and particularly Type 2 diabetes lack effective remedies which address the central determinants of the disease such as insulin resistance and the beta-cell dysfunction. The study aims at finding the potential of polyherbal nanoparticle brews in diabetes treatment. By entrapping the bioactive compounds of Bitter melon (Momordica charantia), Cinnamon (Cinnamomum verum), and Ginseng (Panax ginseng) into nanocarriers, which include liposomes, solid lipid nanoparticles (SLNs), and polymeric nanoparticles, the bioavailability and sustained release of these bioactive compounds are enhanced remarkably. The compositions showed an excellent reduction of blood glucose levels in diabetic rats, the polyherbal nanoparticles formulation showed a reduction of 37 percent, whereas, berberine loaded nanoparticles showed a reduction of 15 percent. In addition, the safety of these formulations was ratified by histopathological examinations and biochemical tests that showed no significant effects on the functions of the liver or kidneys. The results claim that formulations of polyherbal nanoparticles ensignificantly enhance the bioavailability of herbal drugs besides providing superior glucose-lowering effects when compared to conventional treatments. Such an approach represents a new extensive effective strategy to fight diabetes, which has the potential to reduce the side effects caused by synthetic drugs.