Assessment Of Vitamin D3 And Calcium Status In Patients With Graves' Disease In Babylon Province

Abstract

Background:
Graves' disease is a leading cause of autoimmune thyroid disease, and environmental factors, play a significant role in the development of autoimmune thyroid disease. Recent studies have suggested a potential link between vitamin D deficiency and autoimmune thyroid diseases, including graves’ disease. Graves' disease leads to increased thyroid hormone levels triiodothyronin and thyroxine , which can alter calcium homeostasis through several mechanisms. Objective: This study aimed to investigate whether vit D3 and calcium levels are associated with the presence of Graves' disease and potential alterations in thyroid function. This study showed low-level vitamin D3 (17.66 nmol/L), while control group vitamin D3 level was (35.48 nmol/L), with (p-value<0.001) indicates for highly statistically significant. In the same time serum calcium level in patients was significantly lower (1.89 mmol/L) than in controls (2.24 mmol/L), with a P-value( < 0.001), indicating a statistically highly significant difference. Conclusion: This study indicates a significant link between vitamin D3 and calcium deficiencies and the development of graves' disease. We recommend further research on the role and impact of calcium and vit D3 in the pathogenesis and progression of Graves' disease .