Formulation And Evaluation Of Fast Disintegrating Tablets Of Herbal Powder Extracts For Headache

Abstract

Oral medication administration is perhaps the most common method of the dosage form. Researchers have been encouraged by recent technological advancements to produce Fast disintegrating tablets (FDTs) to enhance patient compliance and accessibility. The study was designed to evaluate the composition and efficacy of herbal fast disintegrating tablets for headache care. Herbal powder extracts of Salix alba L (White Willow bark),  Tinospora cordifolia (Guduchi),  Achyranthes aspera (Latjira),  Cyprus rotundus    (Nagarmotha), and  Withania somnifera (Ashwagandha) are produced and processed into fast disintegrating tablets using a super disintegrant including cross povidone, sodium starch glycolate, and micro-crystalline cellulose in various ratios. Several pre-formulation batches (F1-F9) were formed using the direct compression method with various excipient ratios and evaluated pre and post-compression. Weight variation, hardness, friability, thickness, disintegration time, wetting time, content uniformity, in-vitro release, stability study, and IR compatibility were all evaluated on those tablets. According to ICH standards, a stability study was undertaken, and all formulations were determined to be stable. Increased solubility is observed in the UV absorption spectra. F7 and F9 show excellent performance with a disintegration time of 26sec and 24sec, Content uniformity of 98.75 ± 0.04% and 98.65±0.43%, and greater dissolution rate 97.04% and 98.93% at 30 min.