Comparative Study Of Efficacy Of Propofol Auto Co-Induction Versus Midazolam-Propofol Co-Induction Using The Priming Principle In Patients Undergoing Surgeries Under General Anaesthesia

Abstract

Background:Anaesthesia is a balance between anaesthetic drug requirement and state of arousal of patient. Inadequate doses of the drug lead to increased incidence of awareness, while generous administration of drugs leads to hemodynamic instability, delayed recovery, and increase other complications.

Aim: The aim of this study was to assess the effect of the priming principle on dosage response in patients undergoing general anaesthetic surgery utilisingPropofol auto co-induction and Propofol – Midazolam co-induction using bispectral index (BIS).

Objective : The main goal is to calculate total Propofol dose requirement to achieve a BIS value of 45.

Methods:  The study contains eighty patients who were admitted for elective surgeries under general anaesthesia. Patients were randomized into two groups PP and PM where one of the group PP received the priming dose of Propofol 0.4mg/kg body weight followed by induction dose of Propofol(2mg/kg)-10mg every 15 seconds  until BIS value of 45 is attained whereas in the other group PM, priming dose of Midazolam 0.05mg/kg body weight followed by induction dose of propofol(2mg/kg)- 10mg every 15seconds was given until BIS value of 45 is achieved.

Results: All the groups had comparable demographic parameters. The total propofol dose to achieve BIS of 45. The total amount of propofol required  to obtain a BIS of 45 was less in Midazolam-Propofol co-induction group with a statistical significance (P<0.05).

Conclusion:  Priming Principle decreases the dose requirement of propofol required for induction without affecting haemodynamic stability.