Physiological and Biological phenomena of Mixed Ligand Transition Metal Complexes: A Review

Abstract

A coordination compound that has two or more dissimilar type of ligands attached to the central metal atom or ion which is termed as mixed ligand complex or heteroleptic complex.  The complex is made up of several ligands with varied chemical identities bound to a metal center.  A vast array of features are feasible for these complexes. Due to the general combination of interrelated ligands, these complexes display key traits like higher electronic properties, enhanced catalytic efficiency with greater bioactivity. As these complexes seem to be the significant category of coordination compounds, they have been implicated in various fields. Owing to the chelate effect, the chemistry of certain ligands and lipophilicity of the mixed-ligand complexes they have good activity of biological systems.  These complexes have diverse bioactivites such as antibacterial activity, antitubercular activity, antimalarial activity, antifungal activity, anti-inflammatory and analgesic activity, antioxidant activity, anticancer activity and antidiabetic activity.