Hepatoprotective Effect Of Clerodendrum Serratum Seeds Extract On Paracetamol Induced Hepatotoxicity

Abstract

Hepatic damage is associated with distortion of its metabolic functions and it is still a major health problem.Unfortunately many synthetic drugs used in the treatment of liver diseases are inadequate and also cause serious side effects. Clerodendrum serratum (Verbenaceae) is an important medicinal plant growing in the tropical and warm temperate regions like Africa, Southern Asia; Malaysia and distributed throughout in forests of India and Sri Lanka. It is traditionally valued and reported for treating pain, inflammation, rheumatism, respiratory disorders, fever and malarial fever in India with a long history. The aim of this study was to evaluate the hepatoprotective effects of ethayl acetate and ethanol extract of Clerodendrum serratum seed. The values of AST, ALT, ALP, and total bilirubin were all substantially raised by paracetamol. Significant hepatoprotective effects were obtained by pretreatment with Clerodendrum serratumextract. Results of the ethanolic extract of Clerodendrum serratumwere comparable to Silymarin.The current investigation supports the hepatoprotective properties of Clerodendrum serratumseed extract.