Ultra-Sonicated Synthesis Of 1,8-Dioxo-Octahydroxanthenes Ni Multi-Doped Zro2 Nanocatalyst

Abstract

In this study, we report the efficient synthesis of 1,8-dioxo-octahydroxanthenes in excellent yields via the condensation of aldehydes with dimedone, catalyzed by Ni multi-doped ZrO₂ in aqueous medium under both ultrasonic and conventional conditions. This catalytic system offers several advantages, including high yields, strong catalytic activity, operational simplicity, non-toxicity, and an easy work-up procedure. Furthermore, the nanocatalyst can be readily recovered and reused for up to five consecutive cycles without any significant loss of activity.