Pharmacokinetic And Stability Studies Of Lipid-Based Nanoformulations Of Antidiabetic Drugs

Abstract

Lipid-based nanoformulations have emerged as a promising strategy to enhance the pharmacokinetic profiles and stability of antidiabetic drugs, addressing challenges of poor solubility and bioavailability common among these therapeutics.  This research investigates the preparation, characterization, and evaluation of lipid-based nanoparticles, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and self-emulsifying drug delivery systems (SEDDS), loaded with various antidiabetic agents. Pharmacokinetic studies demonstrate significant improvements such as increased maximum plasma concentration (Cmax), area under the curve (AUC), and oral bioavailability compared to conventional formulations. Enhanced drug absorption, sustained release, and reduced first-pass metabolism contribute to these outcomes. Stability studies reveal that lipid-based carriers offer superior protection against physical and chemical degradation, maintaining drug integrity under diverse storage conditions including temperature and pH variations. Moreover, lipid excipients improve drug solubility and lymphatic transport, further optimizing therapeutic efficacy. Safety assessments confirm minimal toxicity and good biocompatibility of the formulations. Overall, this study confirms that lipid-based nanoformulations can significantly improve the pharmacokinetic behavior, stability, and therapeutic effectiveness of antidiabetic drugs, supporting their potential as advanced delivery platforms for diabetes management.